纯度:98% by TLC,;NMR (Conforms)
分子式:C12H8FN3O3S
分子量:293.27
溶剂:DMSO (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):TIMM44 blocker
Function / Pharmacology:MitoBloCK-10 is a first in class TIMM44 blocker. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining function and integrity of mitochondria.1 It induced mitochondrial dysfunction and suppressed angiogenic activity in endothelial cells.1 Targeting TIMM44 by MitoBloCK-10 significantly inhibits bladder cancer cell growth in vitro and in vivo.2