纯度:>98% by TLC;NMR (Conforms)
分子式:C17H12FN3O2S
分子量:341.36
溶剂:DMSO (40 mg/ml)
性状:Cream/off-white solid
存储:-20°C
Activity (short version):Eya2 phosphatase inhibitor
Function / Pharmacology:MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4