纯度:>98% by HPLC;NMR (Conforms)
分子式:C18H22FN3O3
分子量:347.39
溶剂:DMSO (10 mg/ml, warm)
性状:Off-white solid
存储:-20°C
Activity (short version):FOXO1 inhibitor
Function / Pharmacology:AS1842856 is a potent and selective FOXO1 inhibitor, IC50s=33 nM and >1 mM for FOXO3a and 4.1 Oral administration to diabetic db/db mice leads to a reduction of fasting plasma glucose levels.1 Suppresses autophagy, FSP27 expression and adipocyte differentiation.2 AS1842856 is a highly useful tool for probing the involvement of FOXO1 in cellular processes.3-5