纯度:98% by TLC;NMR (Conforms)
分子式:C14H15O3
分子量:245.28
溶剂:DMSO (60 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):RKIP/Raf-1 kinase disruptor
Function / Pharmacology:Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5