纯度:98% by TLC;NMR (Conforms)
分子式:C15H20O2
分子量:232.32
溶剂:DMSO (50 mg/ml) Ethanol (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NFkB inhibitor
Function / Pharmacology:A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NF?B (complete inhibition at 5 ?M)1 acting via inhibition of IKK?6. Isohelenin-mediated NF?B inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6