纯度:98% by TLC;NMR (Conforms)
分子式:C18H18N2O4S2
分子量:390.48
溶剂:DMSO (40 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Rab7 GTPase inhibitor
Function / Pharmacology:A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation.2 Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus.3 Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of b-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway.4