纯度:98% by TLC,;NMR (Conforms)
分子式:C19H16N4O3
分子量:348.36
溶剂:DMSO (40 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PI3K, mTOR and DNA-PK inhibitor
Function / Pharmacology:A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110?, p110γ, p110δ, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6