纯度:98% by TLC,;NMR (Conforms)
分子式:C24H24N6O2S3
分子量:524.68
溶剂:DMSO (10 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):Glutaminase GLS1 inhibitor
Function / Pharmacology:Potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 μM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6