纯度:>98% by HPLC;NMR (Conforms)
分子式:C32H43NO4
分子量:505.7
溶剂:Soluble in DMSO (25 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):Nrf2 activator
Function / Pharmacology:Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress.1 Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro2 and reduces expression of proinflammatory cytokines in vivo3. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro.4 Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.5