纯度:98% by HPLC;NMR (Conforms)
分子式:C62H84N14O6
分子量:1121.45
溶剂:DMSO (50 mg/ml)
性状:White to pale-yellow solid
存储:-20°C
Activity (short version):Smac mimetic
Function / Pharmacology:Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6