纯度:>98% by TLC;NMR (Conforms)
分子式:C43H45BrCl2N3OP
分子量:801.63
溶剂:DMSO (30 mg/mL)
性状:White solid
存储:-20°C
Activity (short version):Mitochondria-targeted antiglycolytic agent
Function / Pharmacology:Antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3