纯度:>98% by HPLC;NMR (Conforms)
分子式:C18H21ClN2O4S
分子量:396.89
溶剂:DMSO (50 mg/mL)
性状:White solid
存储:-20°C
Activity (short version):Rev-Erbα agonist
Function / Pharmacology:Selective Rev-Erbα agonist (EC50=250 nM).1,2 It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 μM).1 GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes.3 In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression.4 It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.5