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Rasarfin
- 英文名称:Rasarfin
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11566
- cas:674359-73-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11566 |
用途 | 科研检测 |
英文名称 | Rasarfin |
包装规格 | 1MG |
CAS编号 | 674359-73-0 |
别名 | Rasarfin |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C23H24ClN3O3
分子量:425.91
溶剂:DMSO (70 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Dual Ras/ARF6 inhibitor
Function / Pharmacology:Dual inhibitor of Ras and ARF6 discovered by screening a library of over 115,000 small molecules employing an endosomal BRET-based assay with the prototypical GPCR angiotensin II type 1 receptor (AT1R) seeking to identify inhibitors of receptor trafficking. IC50=7 and 0.7 μM for ARF and Ras respectively with no inhibition of Rac/Cdc42 and Rho up to 100 μM. It blocks agonist-mediated internalization of AT1R and other GPCRs. It also potently inhibits agonist-induced ERK1/2 signaling by GPCRs and MAPK and AKT signaling by EGFR (IC50=4-5 μM) and prevents cancer cell proliferation. Rasarfin’s direct action on Ras was also verified using purified H-Ras in an in vitro GEF exchange assay.1
分子式:C23H24ClN3O3
分子量:425.91
溶剂:DMSO (70 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Dual Ras/ARF6 inhibitor
Function / Pharmacology:Dual inhibitor of Ras and ARF6 discovered by screening a library of over 115,000 small molecules employing an endosomal BRET-based assay with the prototypical GPCR angiotensin II type 1 receptor (AT1R) seeking to identify inhibitors of receptor trafficking. IC50=7 and 0.7 μM for ARF and Ras respectively with no inhibition of Rac/Cdc42 and Rho up to 100 μM. It blocks agonist-mediated internalization of AT1R and other GPCRs. It also potently inhibits agonist-induced ERK1/2 signaling by GPCRs and MAPK and AKT signaling by EGFR (IC50=4-5 μM) and prevents cancer cell proliferation. Rasarfin’s direct action on Ras was also verified using purified H-Ras in an in vitro GEF exchange assay.1