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Rasarfin
  • 英文名称:Rasarfin
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11566
  • cas:674359-73-0
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-04-30
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11566
用途 科研检测
英文名称 Rasarfin
包装规格 1MG
CAS编号 674359-73-0
别名 Rasarfin
纯度 98+%
分子式
是否进口
纯度:98% by TLC;NMR (Conforms)
分子式:C23H24ClN3O3
分子量:425.91
溶剂:DMSO (70 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Dual Ras/ARF6 inhibitor
Function / Pharmacology:Dual inhibitor of Ras and ARF6 discovered by screening a library of over 115,000 small molecules employing an endosomal BRET-based assay with the prototypical GPCR angiotensin II type 1 receptor (AT1R) seeking to identify inhibitors of receptor trafficking. IC50=7 and 0.7 μM for ARF and Ras respectively with no inhibition of Rac/Cdc42 and Rho up to 100 μM. It blocks agonist-mediated internalization of AT1R and other GPCRs. It also potently inhibits agonist-induced ERK1/2 signaling by GPCRs and MAPK and AKT signaling by EGFR (IC50=4-5 μM) and prevents cancer cell proliferation. Rasarfin’s direct action on Ras was also verified using purified H-Ras in an in vitro GEF exchange assay.1
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