纯度:98% by TLC;NMR (Conforms)
分子式:C15H12ClNO
分子量:257.72
溶剂:DMSO (30 mg/ml)
性状:Pale pink solid
存储:-20°C
Activity (short version):Activates chaperone mediated autophagy
Function / Pharmacology:Atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4