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GW788388
- 英文名称：GW788388
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11570
- cas：452342-67-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11570 |
| 用途 | 科研检测 |
| 英文名称 | GW788388 |
| 包装规格 | 1MG |
| CAS编号 | 452342-67-5 |
| 别名 | GW788388 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C25H23N5O2
分子量:425.49
溶剂:DMSO (18 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):TGF-? receptor kinase inhibitor
Function / Pharmacology:Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase.1,2 Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models.3,4 GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.5
分子式:C25H23N5O2
分子量:425.49
溶剂:DMSO (18 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):TGF-? receptor kinase inhibitor
Function / Pharmacology:Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase.1,2 Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models.3,4 GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.5
