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L6H21
- 英文名称：L6H21
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11575
- cas：24533-47-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11575 |
| 用途 | 科研检测 |
| 英文名称 | L6H21 |
| 包装规格 | 1MG |
| CAS编号 | 24533-47-9 |
| 别名 | L6H21 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C18H18O4
分子量:298.34
溶剂:DMSO (60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MDL/TLR4 interaction inhibitor
Function / Pharmacology:L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 μM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
分子式:C18H18O4
分子量:298.34
溶剂:DMSO (60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MDL/TLR4 interaction inhibitor
Function / Pharmacology:L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 μM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
