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L6H21
- 英文名称:L6H21
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11575
- cas:24533-47-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11575 |
用途 | 科研检测 |
英文名称 | L6H21 |
包装规格 | 1MG |
CAS编号 | 24533-47-9 |
别名 | L6H21 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C18H18O4
分子量:298.34
溶剂:DMSO (60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MDL/TLR4 interaction inhibitor
Function / Pharmacology:L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 μM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
分子式:C18H18O4
分子量:298.34
溶剂:DMSO (60 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MDL/TLR4 interaction inhibitor
Function / Pharmacology:L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 μM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.