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VE-821
- 英文名称:VE-821
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11576
- cas:1232410-49-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11576 |
用途 | 科研检测 |
英文名称 | VE-821 |
包装规格 | 1MG |
CAS编号 | 1232410-49-9 |
别名 | VE-821 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C18H16N4O3S
分子量:368.41
溶剂:DMSO (40 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):ATR inhibitor
Function / Pharmacology:VE-821 is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increases the sensitivity of pancreatic2 and ovarian3 cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells.4 Enhances the cytotoxicity of DNA damaging agents.5
分子式:C18H16N4O3S
分子量:368.41
溶剂:DMSO (40 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):ATR inhibitor
Function / Pharmacology:VE-821 is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increases the sensitivity of pancreatic2 and ovarian3 cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells.4 Enhances the cytotoxicity of DNA damaging agents.5