纯度:>98% by HPLC;NMR (Conforms)
分子式:C11H10N4O
分子量:214.23
溶剂:DMSO (45 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):HDAC3 selective inhibitor
Function / Pharmacology:Potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4