纯度:>98% by HPLC;NMR (Conforms)
分子式:C21H20N4O2
分子量:360.42
溶剂:DMSO (13 mg/ml with warming)
性状:Orange solid
存储:-20°C
Activity (short version):RNA polymerase I inhibitor
Function / Pharmacology:A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 μM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5