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TH10785
  • 英文名称:TH10785
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11588
  • cas:1002801-51-5
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-04-30
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11588
用途 科研检测
英文名称 TH10785
包装规格 1MG
CAS编号 1002801-51-5
别名 TH10785
纯度 98+%
分子式
是否进口
纯度:>98% by TLC;NMR (Conforms)
分子式:C17H21N3
分子量:267.38
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):OGG1 activator
Function / Pharmacology:An 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating DNA repair. TH10785 binds to Phe319 and Gly42 of OGG1 increasing it catalytic activity 10-fold and generating a previously undescribed β,δ-lyase enzymatic function. TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. Increased repair of oxidative DNA damage by small molecules may have therapeutic applications in various diseases and aging.1
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