纯度:>98% by HPLC;NMR (Conforms)
分子式:C19H22N4O4S
分子量:402.47
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NAMPT activator
Function / Pharmacology:NAMPT is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts nicotinamide to nicotinamide mononucleotide (NMN) which is responsible for most of the NAD+ formation in mammals.1 Cellular levels of NAD+ have been shown to decrease with age and NAMPT is believed to be a key enzyme in the aging/senescence process.2 SBI-797812 is a NAMPT activator, turning it into a “super catalyst” that more efficiently generates NMN.3 It increases NMN levels and prevents NAD+ feedback inhibition in a cell-free assay using recombinant human NAMPT at a concentration of 2 μM. In mice (20 mg/kg), it increases liver levels of NAD+ and shows a trend toward increased levels in cardiac tissue but does not affect levels in the quadriceps, or gastrocnemius.3